Thursday, January 10, 2013

Autoinjection Pens for MS

Since the approval of the first disease-modifying drug in 1993, the delivery method of the injectable medications for MS has improved with the development of pre-filled syringes and auto-injection devices.  Initially medications required mixing before they were ready to be injected.  Avonex, Betaseron, and Extavia are available in powered form requiring reconstitution.

The pre-filled syringe was designed to eliminate the need for mixing medication and for easy of use.  Avonex, Copaxone, and Rebif are available in pre-filled syringes.  To assist patients who may have difficulty reaching certain areas of the body for injection, or who have limited dexterity, or who may have a needle-phobia, auto-injection devices are available for use with syringes.  Manufacturers of Betaseron, Copaxone, and Rebif provide auto-injection devices for use with their medication which are designed to be reused and loaded with new syringes for each injection.

A new trend in self-injection technique and methodology is the single-use (disposable), pre-filled autoinjector or pen which comes preassembled, loaded with medication, and ready to use.  The Avonex® Pen™ was approved in February 2012 and just last week the FDA approved the Rebif® Rebidose® pen.  With both the Avonex and Rebif pens, the needle remains covered both before and after injection.  The Avonex® Pen™ is the first intramuscular (IM) autoinjector device approved for MS which incorporates a smaller needle and helps to reduce anxiety about self-injections.

Read this post in its entirety:

Disease-Modifying Drugs for MS: New Single-Use, Auto-Injection Device Approved

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