A number of studies have indicated improvement in MS symptoms, particularly for muscle stiffness and spasms, neuropathic pain and sleep and bladder disturbance, in patients with MS treated with cannabinoids. Trials evaluating other symptoms such as tremor and nystagmus have not demonstrated any beneficial effects of cannabinoids. Safety profiles of cannabinoids seem acceptable, although a slow prolonged period of titration improves tolerability. No serious safety concerns have emerged (Zajicek, 2011).
Recent case reports included in a German study indicate that THC:CBD oromucosal spray is useful in individual patients with moderate to severe spasticity resistant to existing therapies. Researchers were excited to note that improvements in Quality of Life and Activities of Daily Living in some patients with resistant MS spasticity allowed them to engage back in physical and social activities (Koehler, 2014).
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Can Medical Marijuana Help Control MS Symptoms?: A HealthCentral Explainer