Estriol and Pregnancy
Pregnancy is characterized by the presence of potentially immunomodulatory and neuroprotective hormones including estrogens, cortisol, progesterone, and prolactin. It is believed that the secretion of these factors are important for the CNS neuronal and oligodendroglial cell lineages during development of the baby. The mother’s body goes through many other changes as well.
Estriol is the estrogen hormone which is most significant for multiple sclerosis. It is produced by the placenta during pregnancy and seems to have a protective quality on the immune system, as well as the central nervous system, for the mother. Used therapeutically, estriol has been shown to have anti-inflammatory as well as neuroprotective effects in women with MS.
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MS in Men and Women: The Role of Estriol in Women